Search results for "Rhabdoviridae Infections"

showing 2 items of 2 documents

Evolutionary history conditions the timing of transmission in vesicular stomatitis virus.

2001

It has been postulated that early transmitted viruses would evolve to be more virulent than late transmitted ones. The reason for this prediction is that early transmission selects for rapid viral replication and, consequently, rapid host death, whereas late transmission would select for slow-replicating viruses that permit longer survival to the host. To test this prediction, experimental lineages of vesicular stomatitis virus (VSV) had been adapted to three different transmission dynamics during more than 100 generations. Transmission dynamic differed in the stage of infection at which transmission took place: early, intermediate or late. Regardless the timing of transmission imposed duri…

Microbiology (medical)Time FactorsVirulenceVesicular stomatitis Indiana virusBiologyVirus ReplicationMicrobiologyModels BiologicalVirusVesicular stomatitis Indiana viruslaw.inventionlawRhabdoviridae InfectionsGeneticsHumansMolecular BiologyEcology Evolution Behavior and SystematicsGeneticsExperimental evolutionVirulenceHost (biology)biology.organism_classificationVirologyBiological EvolutionInfectious DiseasesTransmission (mechanics)Viral replicationVesicular stomatitis virusInfection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
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Transmission bottlenecks and the evolution of fitness in rapidly evolving RNA viruses

2003

We explored the evolutionary importance of two factors in the adaptation of RNA viruses to their cellular hosts, size of viral inoculum used to initiate a new infection, and mode of transmission (horizontal versus vertical). Transmission bottlenecks should occur in natural populations of viruses and their profound effects on viral adaptation have been previously documented. However, the role of transmission mode has not received the same attention. Here we used a factorial experimental design to test the combined effects of inoculum (bottleneck) size and mode of transmission in evolution of vesicular stomatitis virus (VSV) in tissue culture, and compared our results to the predictions of a …

Microbiology (medical)virusesKidneyMicrobiologyVesicular stomatitis Indiana virusBottlenecklaw.inventionEvolution MolecularGenetic driftlawCricetinaeRhabdoviridae InfectionsDisease Transmission InfectiousGeneticsAnimalsMolecular BiologyCells CulturedEcology Evolution Behavior and SystematicsGeneticsExperimental evolutionbiologyGenetic Variationbiology.organism_classificationInfectious Disease Transmission VerticalInfectious DiseasesTransmission (mechanics)Vesicular stomatitis virusMutation (genetic algorithm)AdaptationHorizontal transmissionInfection, Genetics and Evolution
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